“La nave dei folli”
di Marco Taddei
Illustrazioni di Michele Rocchetti
Orecchio Acerbo, 2016
(per tutti)
Brandano, stagionato perdigiorno, il figlio del bottaio di Saggionia, decise di intraprendere un viaggio per dimostrare (cosa che avea vista in un sogno) che la terra è rotonda.
Gli fu offerta dal borgomastro una bagnarola con l’invito di attraversare il mare e provare qual che andava sperticando.
La ciurma, invece, fu più facile da recuperare: l’unica merce che i mercanti davano via erano i mentecatti, di cui le pubbliche galere erano strapiene.
Con ciurma e vascello, Brandano prende il mare e, novello Ulisse, si appresta a vivere rutilanti avventure: vichinghi aromatizzati al bergamotto, mostri marini, draghi dorati, principesse clandestine, pesci giganti, financo l’Inferno e… la fine del mondo, dove si fabbricano i soli, ma ne fabbricano solo uno al giorno così non è dato di sapere quanto ci resta da vivere su questa terra.
Eppure Brandano infine suggellò il suo sogno: partito con una bagnarola verso una direzione, ne tornò a piedi dall’altra, dimostrando così la pinguedine della terra.
Spettacolari illustrazioni a metà strada tra il naiv e i codici miniati!
H!
http://www.orecchioacerbo.com/editore/
(immagine: la copertina del libro)
One reason why Deca Durabolin may have a particularly unfavorable effect on sexual libido and performance is that it considerably increases prolactin ranges in the bloodstream.
Arguably the most infamous side effect is ‘Deca dick,’ which essentially is erectile dysfunction or impotence.
Our sufferers have reported an incapability to
get erections and significantly reduced libidos. Significant
decreases in pure testosterone production are a certainty when taking any steroid.
It also lacked large-scale epidemiological research; the
majority of studies had been primarily based on a small inhabitants.
The information on the association between AS and long-term cardiovascular
morbidity and mortality are limited. As such, in this article, we shall be looking the available literature with the PubMed
database to analyze the association between AS use and CVD
growth because of the high prevalence of AS use.
Today, their use extends far beyond the realm of elite athletes, seeping into
highschool locker rooms, local gyms, and even the workplaces of
white-collar professionals looking for an edge within the rat race.
Females who use steroids might have problems with their menstrual cycles because steroids
can disrupt the maturation and launch of eggs from the ovaries.
Men and boys with muscle dysmorphia (a sort of physique dysmorphic disorder) see themselves
as not muscular sufficient and can abuse steroids in a bid to repair this perceived flaw.
Steroid abuse is the usage of steroids for efficiency or image-enhancing causes like enhancing athletic capacity and constructing muscle.
They make headlines when sports stars are caught out, and
they’re a subject of speculation when someone’s bulked up shortly
— but how much do you actually know about steroids?
From how they work to widespread unwanted side effects, we’re explaining every
thing you should know.
We have found extremely androgenic steroids (such as trenbolone and testosterone) to own extra pronounced fat-burning properties because of
androgen receptors having a more potent effect on the reduction of adipose tissue.
The basic population is aware of the dangers that anabolic steroids pose,
with the media often reporting horror tales of women and
men abusing PEDs. Think About spending years honing your body to perfection, solely
to seek out that your mind has turn into a foggy, unreliable mess.
For many steroid customers, this cognitive decline can be just as devastating as any physical unwanted aspect effects.
It’s a cruel irony that the very medication meant to reinforce performance
can finally undermine the mental faculties wanted to succeed in life.
The identical holds true for world longitudinal strain in nonhypertensive people (218).
The isovolumic leisure time is also an impartial predictor
of coronary heart failure within the basic inhabitants
(219). Consequently, an argument could presumably be made to perceive these AAS-induced cardiac modifications as
risk modifiers when estimating CVD danger using algorithms such as SCORE2 or PCE, and
will assist in ‘grey zone’ risk estimation situations.
Some initial information regarding the time course of HPGA
recovery after AAS use have just lately been printed
(176). When gonadal function was regular earlier than an AAS cycle, there was a 90% probability of having normal testosterone levels
3 months after cessation and a 100% probability on the end of follow-up (1 year after the start of the cycle).
Creatinine is, for essentially the most part, a product of the spontaneous nonenzymatic degradation of creatine (Cr) and
creatine phosphate (PCr) (159). The overall conversion price for the entire Cr pool (Cr + PCr)
is (almost) fixed and approximately 1.7% day by day.
Given that nearly the entire body’s creatine is saved in skeletal muscle,
an increase in muscle mass increases the day by day
manufacturing of creatinine and can subsequently elevate
serum creatinine ranges with out impacting GFR. The eGFR primarily
based on serum creatinine levels is therefore an underestimate
in muscular populations. Oral AAS again demonstrate unfavorable changes, constantly growing LDL-cholesterol (38, 118, 121, 125, 126).
In the HAARLEM research, LDL-cholesterol elevated by 0.45 mmol/L in contrast
with baseline (46).
The alteration of hepatic metabolism was famous to
cause pressure on the liver, and indeed all oral compounds with this C-17 addition have been discovered to trigger dose-related hepatotoxicity.
This small change was additionally found to decrease these agents’ interplay with aromatase.
[7] Subsequently, even small changes to these father or mother compounds cause a number
of alterations in the inherent nature of AASs. Medical interest in the
beneficial effects of those medicine has increased, and ongoing analysis will proceed to uncover novel uses for these brokers and will further outline their mechanisms of action. The danger
for and severity of these unwanted effects increases in parallel
with the period of use and dosage. Some unwanted facet effects occur in both women and men while others are
intercourse particular. Doctors prescribe corticosteroids primarily to minimize
back harmful irritation in the body because of a variety of situations, similar to Crohn disease, ulcerative colitis,
a quantity of sclerosis, lupus and rheumatoid arthritis.
However, this does not preclude the likelihood that these changes would possibly turn out to be
permanent with more extended AAS use or with repeated cycles that provide too little time
for recovery to take place in between. This is especially worrisome as there
is considerable evidence that myocardial damage, which may accumulate in years
of ongoing AAS use, is a major trigger for sudden cardiac death in AAS users (217).
Technological advances have led to extra sensitive measurements of cardiac structure and performance.
Similar outcomes were reported by Krieg et
al. who noticed a decreased Em/Am ratio on the basal part of the
interventricular septum in a small group of AAS-using bodybuilders compared with steroid-free strength athletes
and sedentary controls (216). Em/Am ratio is the ratio between the rate of
the myocardial wall throughout early diastole (Em) and late diastole (Am), and a
lower in this ratio is indicative of diastolic dysfunction.
The premise of hormonal male contraception hinges on the negative feedback
exerted by intercourse hormones on LH and FSH secretion. Apparently, even a dosage that is roughly twice that of
TRT (200 mg testosterone enanthate weekly) solely partially suppresses LH (-66.7%) and FSH (-62.5%)
and, certainly, leads to azoospermia in solely about two out of three
men (182).
Death et al. (2004) demonstrated that THG was
about one order of magnitude more potent than nandrolone, testosterone
and trenbolone in yeast cells expressing human androgen receptors.
Friedel et al. (2006b) additionally used a reporter gene assay based in a yeast strain containing transfected androgen receptor constructs and located that THG was
about 10 instances decrease than the EC50 of the reference substance DHT.
The authors make the important point that it isn’t recognized whether yeast-based techniques specific the repertoire
of coregulators that’s current in mammalian androgen-responsive tissues.
Labrie et al. (2005) studied the genomic signature of THG and in contrast
it with the effects of DHT on gene expression in mouse tissues
by extracting RNA, changing it to cDNA and then transcribing it in vitro
to supply biotinylated cRNA for analysis. These
investigators found that THG and DHT modulated
in a similar fashion 671 genes in the mouse levator ani muscle, ninety
five genes in the gastrocnemius muscle and
939 genes in the prostate. In the male foetus, androgens stimulate the
development of the Wolffian ducts (epididymis, vas deferens, the seminal
vesicles and ejaculatory duct) and the male external genitalia (penis, urethra and scrotum) (Wilson et al., 1981).
Every steroid has a special chemical construction,
and even slight differences can alter the pace at which
it’s metabolized or how long the steroid’s metabolites will remain within the body (and therefore,
its detection time). We also can think of metabolites on account of changing
one chemical compound into one other. So, whereas it’s
pointless to be a chemistry professional to know
that metabolites are a key consider any steroid drug testing, you will
need to understand how long these metabolites can stay in your system.
One of essentially the most significant monetary risks of shopping for steroids is when you don’t obtain them; you both obtain fakes or get
nothing. But by sticking with recognized, reputable,
and trusted sources, you need to be succesful of stay confident that you simply won’t be throwing money at scammers or counterfeiters.
It can typically take a couple of months after stopping
your PED cycle before your regular menstrual cycle resumes.